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Reviewing the team's patent and related documents at Talpos's request, Anna Mapp, the Edwin Vedejs Collegiate Professor of Chemistry at the University of Michigan, and also the President of the American Peptide Society, questioned the limited detail available and the absence of a published sequence for the peptide's parent protein, an omission she noted makes the original work impossible to reproduce

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Our findings raise the possibility that the dysfunction of this gene alters the delicate glutathione balance in the ER and leads to protein misfolding during brain development, Liu says