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The cerebrovasculature is a very bioenergetically active tissue with capillary endothelial cells having been shown to possess five times more mitochondria than muscle cells (Oldendorf and Brown, 1975) and transport 10 times their weight in glucose each minute across the BBB, along with accomplishing other energetically costly cellular processes (Cunnane et al., 2011)

Keaton, J

What makes sense is that persistent HO-1 stimulation diminishes hyperglycemia and enhances glucose metabolism while shielding renal tissues, partially or entirely, against hyperglycemic injuries

Materials and methods Animals Male Sprague Dawley rats (total n = 133