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In a randomized controlled trial assessing the effects of butyrate in obese children, there was a consistent response which showed a significant reduction of bodyweight and waist circumference compared to placebo [4]. Per-protocol analysis in the butryate group revealed a decrease in BMI of 2.26 units and a reduction in waist circumference by 5.07cm in 6 months [4]

In addition, curcumin positively affects body weight and glucose, increases GPx activity (165), and decreases FFA, triglycerides, and cholesterol concentrations in diabetic rats (15)

Moreover, the limit of solubility of urate in physiologic solutions is 6.7 to 7.0 in vitro at 37 o C

Its antioxidant efficacy was also proven for hypochlorite-induced damage