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Dr Sonya Babu-Narayan, the clinical director of the British Heart Foundation, said semaglutide had proven benefits beyond reducing the number on the scales and weight-loss drugs were now considered important medicines for preventing cardiovascular events

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Randomised crossover studies in healthy individuals using infusion of labelled individual amino acids combined with isotope tracing and accurate measurements of glucagon are required

Most evidence comes from small observational studies and off-label use reports rather than large randomized controlled trials