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These reactive species are necessary in small amounts for processes like cell signaling, but when overproducedoften due to poor lifestyle habits like smoking, an unhealthy diet, or exposure to pollutionthey start to attack and damage healthy cells

For this reason, a large number of superoxide dismutase conjugates have been developed with a longer half-life in the bloodstream, high stability and less immunogenicity

It is important to note that this mechanism, while biologically plausible, is not yet validated by large-scale controlled trials, and individual results vary considerably depending on baseline melanin levels, skin type, and dosage

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