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Clinical studies demonstrate that individuals using Ozempic experience significant reductions in body weight compared to placebo groups

Important safety considerations include a boxed warning regarding thyroid C-cell tumors observed in rodents (though the relevance to humans is unknown) and contraindications for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

In this sense, as expected, the combination of empagliflozin and semaglutide significantly decreased glucose by 112 mg/dL (CI95%: 36190, p = 0.006) more than empagliflozin alone (Figure 1A)

Meanwhile, the reduction in SCFA-producing and immunomodulatory taxa such as Lactobacillus implies a weakened gut barrier and a pro-inflammatory microbial profile conducive to endothelial dysfunction (Tang et al., 2019