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Figure 5 3.9 DNA methylation scores correlate with skin disease activity Next, we explored the relationship between skin psoriasis disease activity, based on PASI scores, and changes in DNA methylation including matched samples from skin psoriasis and PsA patients before and after treatment

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Diminishing returns become apparent after 4 to 6 months for skin-related goals, at which point maintenance frequency (2 to 3 injections per week) replaces loading