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In a study that evaluated the efficacy of Bupi Shugan Decoction combined with sound therapy in 64 patients with chronic tinnitus attributed to liver depression and spleen deficiency who also presented with anxiety symptoms, compared with sound therapy alone, the combination treatment significantly improved THI, VAS, Self-Rating Anxiety Scale (SAS), and TCM syndrome scores, indicating symptomatic relief, anxiety reduction, and improved quality of life

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