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SKU: 66355771444
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SKU: 66355771444

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General anesthesia triggered gene expression changes consistent with astrocytes being in a low-activity environment, but additionally caused induction of a reactive profile, with transcriptional changes enriched in those triggered by stroke, neuroinflammation, and A/tau pathology

The study also revealed the underlying mechanism: autoantibodies and IFN- in SLE serum enhance the binding of the transcription suppressor CREM to the Gpx4 promoter, which in turn suppresses Gpx4 expression