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As an integral part of the cellular membrane, omega-3 PUFAs regulate membrane fluidity and complex assembly in lipid rafts 710

In general, BCRP substrates share a same set of molecular properties as that of substrates to P-gp and other efflux pumps (Begley 2004, Kunta and Sinko 2004, Takano et al

Levels decline with age, stress, alcohol, poor diet, and toxin exposure

NAC has been reported to exhibit cytotoxicity at variable concentrations depending on cell type: 10 mM NAC was nontoxic in human bronchial epithelial cells [17], 40 mM was nontoxic in 3T3 fibroblasts [27], and 50 mM was nontoxic in aortic endothelial cells [17]