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Wound healing: time to look for intelligent, natural immunological approaches

Considering whey proteins score above almost all other proteins on the PDCAAS (Protein Digestibility Corrected Amino Acid Score) chart, the gold standard for assessing digestibility and absorption of amino acids, it has been a focus of product creation with more of an emphasis on WPI90 (90% protein by volume) as opposed to the historic leader, WPC80 (80% protein by volume)

However, the use of ERK1/2 or JNK inhibitors inhibited the growth of colon cancer cells in vivo and in vitro, suggesting that the activation of ERK1/2 and JNK signaling by insulin and IGF-1 is at least partially responsible for the development of T2DM-associated colon cancer (96)

This also significantly elevated pro-inflammatory factors IL-6, TNF-, and IL-1 in the cerebrospinal fluid, and upregulated lipoxygenase (LOX), PTGS2, IL-6, and TNF- expression in microglial cells, which further promote inflammatory activation