Furthermore, the literature also focused on the succinylcholine-induced neuromuscular junction blockade [102], local anesthesia [103,104] (i.e., via lidocaine intraplantar application and axillary and spinal (L4-L5) intrathecal block [103]), electrolytes disturbances [19,55,80,105,106], neuroleptics dopamine blockade [26,51,54,55], NO-system blockade [26], alcohol intoxication [22], serotonin syndrome [25], particular neurotoxins (inducing Parkinson-like disturbances in mice [30] or multiple sclerosis-like disturbances in rats [31]), and tumor cachexia [10]
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Cost, manufacturing, reproducibility Synthesising D-retro-inverso peptides with high purity is non-trivial