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[2] Nitric Oxide System & Endothelial Research Research applications include studies of: Endothelial nitric oxide synthase (eNOS) modulation through upstream kinase pathways Caveolin-1 (Cav-1) binding interactions with eNOS in cell culture Nitric oxide (NO) production mechanisms and microcirculatory effects in vascular models Platelet aggregation pathways in coagulation research Studies examine NO production mechanisms following cav-1 displacement in endothelial cell models and microcirculatory perfusion in preclinical research systems

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Copper is held by three nitrogen donors the glycine -amino nitrogen, the deprotonated GlyHis amide nitrogen and the histidine imidazole while the lysine side chain stays free