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Finally, the oxidative stress and protein nitration causes the opening of the mitochondrial membrane transition pore (MPTP) leading to the collapse of the membrane potential and cessation of ATP synthesis, which is the cause of cell death [37, 38]

This is not overkill

Neurochem Res 41(12):32893299 Wang Y, Jin S, Sonobe Y, Cheng Y, Horiuchi H, Parajuli B, Kawanokuchi J, Mizuno T, Takeuchi H, Suzumura A (2014) Interleukin-1 induces bloodbrain barrier disruption by downregulating sonic hedgehog in astrocytes

Maturation of oligodendrocytes is more sensitive to TNF alpha than is survival of precursors and immature oligodendrocytes