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Malinow MR, Nieto FJ, Szklo M, Chambless LE, and Bond G (1993)

Numerous signaling proteins have been shown to be succinated including PTEN (phosphatase and tensin homolog)

They used a two compartments device, realizing a non-autologous supportive vascularized channel, obtained by seeding human umbilical vein endothelial cells (HUVECs), and an autologous hematopoietic channel with a 3D co-culture of human CD34 + cells and bone marrow-derived mesenchymal stromal cells (BMSCs) in a fibrin gel

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