Growth and apoptosis Ex-4 significantly improves the survival of rat cortical neurons under oxygen/glucose deprivation (OGD) conditions through reduced apoptosis rates, increased expression of glucose-regulated protein 78, and decreased levels of C/EBP-homologous protein, indicating the role of Ex-4 in modulating unfolded protein response for protecting neurons from ischemic damage [56]
Am J Hypertens 27(1):130139 Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ (2013) GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
It can either increase LH surge in HPO axis disturbances due to adipose tissue estrogen aromatization or decrease too high LH levels (inducing ovarian androgen secretion) connected with hyperinsulinemia
Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion