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CARDIOVASCULAR EFFECTS OF GLP-1 RAs IN HUMAN STUDIES Blood pressure and heart rate Circulating biomarkers and lipid profiles Carotid intima-media thickness LV function and reperfusion injury in patients with coronary artery disease Retrospective studies on cardiovascular outcomes A prospective randomized clinical trial with primary cardiovascular outcome: the ELIXA study Preclinical and preliminary clinical evidence has consistently revealed potential cardiovascular benefits from the administration of GLP-1 RAs

Unlike the reversible albumin binding used by GLP-1 agonists, the DAC forms an irreversible bond with serum albumin, creating a circulating depot that extends the half-life of a GHRH analog from minutes to days

doi: 10.1056/NEJMoa2416394 Fahim SA, Attia YM, et al

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