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By suppressing NF-kB, KPV reduces the expression of pro-inflammatory cytokines including IL-8 and monocyte chemoattractant protein-1 (MCP-1)

449 A gene array meta-analysis also revealed sex differences in MDD, with depressed females being more likely than depressed men to have lower production of somatostatin, a GABA neuron biomarker in corticolimbic brain regions according to postmortem analysis

Since Asians made up only a fraction of the examined participants, the authors speculate that a more balanced distribution of participants might alter the overall results

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