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Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes
All discrepancies between reviewers were resolved through consensus-based discussions with a senior researcher (LZ)
In our recent studies, we have identified a different inhibition mechanism of TGR in which an inhibitor binds non-covalently at the so-called doorstop pocket interfering with enzyme function 33,34
As for CYP3A5 and CYP2C19, there was no significant correlation between CYP3A5*3 and the plasma concentrations of tamoxifen and its metabolites
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