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It has been reported that ROS can act as signaling molecules to regulate antioxidant and pro-oxidant system, such as by activating or inhibiting NF-B signal [54, 55]

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Cannon CP, Pratley R, Dagogo-Jack S, Mancuso J, Huyck S, Masiukiewicz U, Charbonnel B, Frederich R, Gallo S, Cosentino F, Shih WJ, Gantz I, Terra SG, Cherney DZI, McGuire DK, Investigators VERTISCV