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So long as the brand-name options remain pricy, theres incentive for 503As to create these slightly changed versions

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The mechanism of tumour suppression involves multiple pathways

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They discovered that the binding of a peptide mimicking the MDM4 C-terminus tail to MDM2 impairs MDM2-mediated ubiquitination of p53 and promotes p53-dependent transcription and oncosuppressive activities [57]

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