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The most frequently reported early effects include nausea, mild stomach discomfort, bloating, gas, and occasional diarrhea or constipation

The ramifications of midlife weight gain extend far beyond aesthetics, contributing to an increased risk of heart disease, type 2 diabetes (T2D), and other metabolic disease

They may nudge reward circuits that drive our urges, and that may explain why some people notice less food noise, thoughts and why research is starting to test GLP ones in Alzheimer's disease and even alcohol use disorder

The retatrutide dose schedule follows a similar escalation pattern, suggesting it will likely require long-term use for sustained benefit