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For example, in pea plants susceptible to Plum pox virus (PPV), systemic PPV infection produced chlorotic and necrotic lesions, a pronounced oxidative stress indicated by increased protein oxidation, lipid peroxidation, elevated H 2 O 2 levels and electrolyte leakage in infected leaves (Daz-Vivancos et al., Rice black-streaked dwarf virus (RBSDV) displayed an induction of GST23 and the corresponding transcripts, concomitant with oxidative stress (Xu et al., 2013)

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10.1176/appi.ajp.2015.14101358 23 BolzS

Meta-analysis of randomized controlled trials shows L-carnitine supplementation significantly reduces CRP (weighted mean difference -1.23 mg/L), IL-6 (-0.85 pg/dL), and TNF- (-0.37 pg/dL), with greater effects observed in studies exceeding 12 weeks duration.[4] In obese patients, L-carnitine combined with synbiotics reduced IL-6 by 34%, hs-CRP by 10%, TNF- by 19%, and malondialdehyde by 22%.[5] L-carnitine also improves inflammatory markers in chronic kidney disease, cardiovascular disease, and metabolic conditions.[6] Acetyl-L-carnitine offers distinct advantages for neuroinflammation through multiple mechanisms beyond simple carnitine delivery