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NOT recommended for treatment of type 1 diabetes or treatment of diabetic ketoacidosis Pharmacokinetics: oral administration, 65% bioavailability activity is terminated by conversion to inactive O-glucuronide metabolites (that are eliminated in the urine), with only minimal (~7%) metabolism by CYP3A4

In the 2022 SURMOUNT-1 study published in NEJM, three doses of tirzepatide were compared with placebo (1:1:1:1) to determine effects on percent weight change over the course of 72 weeks

Early research suggests GLP-1 receptor agonists may reduce migraine frequency in some people, possibly through effects on intracranial pressure