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An early multicenter, randomized, placebo-controlled study in individuals with AD of moderate severity found that supplementation with 2,000 IU/day of all - rac --tocopherol (equivalent to 900 mg/day of RRR --tocopherol) for two years significantly delayed cognitive decline, slowed disease progression, and increased median survival (107)

A 2024 meta-analysis and systematic review by Bell and colleagues investigated brain glutathione levels in individuals with depression using proton magnetic resonance spectroscopy (H-MRS)