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In serum, first-episode, antipsychotic-nave patients show reductions in TRP, KYN, KYNA, anthranilic acid, and modestly lower 3-HK and QA, indicating early KP dysregulation, and long-term antipsychotic treatment partially normalizes these metabolites [238]

The synthetic peptide was infused intraventricularly directly into the brain ventricles at 6 nmol/kg in rabbits, under double-blind conditions against control solution and eight related peptides