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The researchers concluded that most of these hormonal changes (particularly TSH and free T3) appeared to be independent of weight loss, suggesting a possible direct effect of semaglutide on thyroid regulation that still needs to be clarified, while changes in free T4 were more closely related to weight change

In 2020, it was FDA approved to help lower the risk of serious heart problems, such as heart attack, stroke, and cardiovascular-related death, in people with type 2 diabetes and heart disease

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