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Renowned for its ability to replenish levels of the antioxidant glutathione, it also regulates the important neurotransmitter glutamate
Structure of oxidized GPX4 U46C is based on crystal structure reported in this work
(c) nuclear translocation of predominantly p65/p50 dimers to induce transcription of target genes, including well-established FLICE-like inhibitory protein (c-FLIP) and apoptosis protein inhibitors (c-IAP)
This imbalance reflects a disrupted MMP/TIMP axis, contributing to excessive ECM degradation and delayed wound healing in DFUs
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