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While during this time frame the percentage of new users with type 2 diabetes decreased, there was a twofold increase in the proportions of users without type 2 diabetes and a BMI of 30 kg/m 2 or greater, as well as in participants with a BMI of 27 to 30 kg/m 2 and an obesity-related comorbid condition

Yang L, Wang LWJ, Wang Y

Furthermore, fatty acid oxidation (FAO) is markedly upregulated in resistant tumor cells, providing additional substrates such as acetyl-CoA and propionyl-CoA to fuel the TCA cycle via citrate synthase and succinyl-CoA synthesis (251, 252)

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