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The same covalent mechanism of action was previously demonstrated for another PAM of GLP-1R (i.e., BETP), showing that in addition to C347, BETP also formed a covalent adduct with C438 in the C terminus 27 that is invisible in the current GLP-1R complex structures

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This means they're involved in regulating a host of other functions: Appetite and Energy Homeostasis (MC3R & MC4R): These receptors in the brain are critical for controlling food intake and energy expenditure

This is why a consultation with a trained professional should precede any treatment, to assess your individual needs and possible contraindications