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An early proof-of-concept analysis from the ongoing RESTORE trial at the University of Colorado Anschutz, published in Fertility and Sterility in June 2026, found improved reproductive measures in participants aged 12 to 35 who achieved at least 10 percent weight loss on injectable semaglutide

Semaglutide injections are administered once weekly into subcutaneous fat (usually the abdomen, thigh, or upper arm), which contains abundant small blood vessels

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