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In the ATTAIN-2 trial, participants lost an average of 22.9 lbs (10.5 percent) on the highest (36mg) dose of orforglipron, with A1C reduced by an average of 1.8 percent

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This work was supported by the Funds of the National Natural Science Foundation of China (82060728), the Guizhou Provincial Science and Technology Department (MS [2025-380], Thousand Talents Program), the Talents of Guizhou Science and Technology Platform [2021]1350-009, the Zunyi Science and Technology Bureau (HZ-2023-173, HZ-2023-09, [2024] No

Finally, sections were mounted with anti-fluorescence quenching mounting medium (with DAPI) (Solarbio) and imaged using microscope with consistent laser power and gain settings across samples