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The second is neural, where GLP-1 activates vagal nerve afferents in the gut wall that transmit satiety signals directly to the nucleus tractus solitarius (NTS) in the brainstem

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Semaglutide (Ozempic and Wegovy) was found to be more effective than liraglutide (Saxenda and Victoza): overall, participants who took semaglutide lost 5.1 percent of their body weight, compared with just 2.2 percent among those taking liraglutide