In susceptible patients, these pressures may increase mitochondrial stress, raise SAH, lower the SAM-to-SAH ratio and create a functional undermethylation pattern that contributes to depression, anxiety, brain fog, fatigue and medication sensitivity
Abstract FOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell maintenance, cancer, metabolic, and cardiovascular diseases
The membranes were then incubated overnight at 4 C with the following 14 primary antibodies diluted to 1:2000 in 1% TBST: mouse anti-CYP1A2 (sc-53614), mouse anti-PFK-1 (sc-166722), mouse anti-fatty acid synthase (A-5) (sc-55580), mouse anti-PKLR (sc-133222), mouse anti-GSTM1 (sc-517262), mouse anti-CROT (H-1)(sc-365976), mouse anti-PROHIBITIN 2 (A-2) (sc-133094), mouse anti-ATP5F1 (C-12) (sc-514419), mouse anti-CYP4A1(clo1) (sc-53248), mouse anti-PKM (C-11) (sc-365684), mouse anti-GSTT2 (D-1) (sc-514667), mouse anti-FAAH (27-) (sc-100739), mouse anti-17-HSD2 (E-7) (sc-374150), mouse anti-GSTA1/2/5 (E-6) (sc-398714), mouse anti-ETFDH (D-2) (sc-515202), mouse anti-LFABP (C-4) (sc-374537), mouse anti-LMP2,1i (A-1) (sc-271354, LOT#B1611), mouse anti-MECL-1(71P6) 2i (sc-130295) (all from Santa Cruz), mouse anti-5i (1:2000, custom made by Abgent), and rabbit anti-PSMA6 (1:20,000
Nakai M, Iadecola C, Ruggiero DA, Tucker LW, Reis DJ
