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Moreover, by adding known concentrations of DOX and metacycline to blank plasma samples, the linearity and reproducibility were excellent within the linear range of 0.2510 g/mL, regression correlation coefficient (r 2 ) exceeding 0.99 (Table 2)

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The appearance is consistent across patient ages, though older patients tend to experience it more dramatically because they have less collagen reserve and less skin elasticity to compensate for the structural changes

Nothing here is sold as a quick fix or a guaranteed number, and several of these work best over time rather than in a single visit