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Methane, mainly produced by Methanobrevibacter smithii, increases smooth-muscle tone and slows transit, contributing to slow-transit constipation ( 2 S), another gaseous metabolite, acts as a signalling molecule with biphasic effects: low concentrations promote relaxation, whereas higher levels inhibit propulsion, indicating a complex modulatory role in motility control ( In methane-positive or bloating-prone individuals, targeted suppression of methanogens with antibiotics or dietary modulation of fermentable substrates has been shown to improve transit time ( Short-chain fatty acids (SCFAs), the main products of gut microbiota fermentation of soluble fibers, activate free fatty acid receptors (FFAR2 and FFAR3) on enteroendocrine L cells, stimulating GLP-1 and PYY secretion and modulating motility (Yano et al., 2015)
The current recommendations are that GLP 1 agonists may be continued in the perioperative period when used for diabetes
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A study published in the New England Journal of Medicine found that individuals taking semaglutide for 68 weeks lost an average of 14.9% of their body weight
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