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39 , 55 , 56 Complementary to these paradigms, intracerebroventricular (ICV) models employing lipopolysaccharide (LPS), 57 amyloid oligomers, 58 or streptozotocin 59 can induce acute or chronic central inflammation independently of peripheral metabolic cues

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In addition, NAC shows an enhanced effect to improve liver function by reducing the levels of oxidative stress and pro-inflammatory markers such as IL-6, TNF- and IL-1, NF-B, TGF-1, and MDA levels (Table 2, Figure 3)