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Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)
In contrast, the NAD+ precursor NR has been extensively researched and featured in over 35 peer-reviewed clinical studies across various populations and conditions
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