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Off-drug weight regain was observed and was accompanied by worsening glycemia and increase in progression to type 2 diabetes. Three-year safety of tirzepatide for weight loss Sean Wharton Sean Wharton, MD, FRCPC, PharmD , medical director of the Wharton Medical Clinic, adjunct professor at McMaster University in Hamilton, Ontario, and York University in Toronto, academic staff at Womens College Hospital and clinical staff at Hamilton Health Sciences, presented the main safety results of the 3-year trial