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In conclusion, compound 20 in the biphenyl-substituted triazole group, as well as compounds 21 and 22 in the acetoxy- and monophenyl-substituted triazole groups, demonstrated the highest potency for inhibiting DPP-4 (99) (Figure 4)

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Most common long-term side effects are gastrointestinal: nausea, vomiting, diarrhea, and constipation

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