The determined cryo-EM structure of human RNF213 and the crystal structure of the IpaH1.4 LRR/RNF213 RING complex elucidate the molecular mechanism by which IpaH1.4 specifically target RNF213
Diabetologia 110 Hernn MA, Alonso A, Logan R, Grodstein F, Michels KB, Willett WC, Robins JM (2008) Observational studies analyzed like randomized experiments:an application to postmenopausal hormone therapy and coronary heart disease
45 TatR.CermolaM.RiccioA.Diez-RouxG
10 / 2026 Zealand Pharma announces Boehringer Ingelheim's novel glucagon/GLP-1 dual agonist survodutide achieved significant weight loss of 16.6% delivering meaningful metabolic improvement in people living with obesity or overweight in Phase 3 trial In SYNCHRONIZE-1, participants lost up to an average of 39.2 lb (17.8 kg) from baseline after 76 weeks of treatment with survodutide, a glucagon/GLP-1 receptor dual agonist1 The trial met both weight loss primary endpoints and its key secondary endpoint evaluating waist circumference, a predictor of cardiometabolic risk, together demonstrating survodutide's potential to broadly improve metabolic health1 In addition to these positive results, Boehringer is advancing its broad metabolic health R&D program, exploring multiple pharmaceutical approaches to weight management including oral treatments
