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The company's clinical trial data indicates weight loss outcomes with oral Wegovy are similar to those observed with injectable Wegovy in separate trials, though direct head-to-head comparison studies have not been conducted

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FDA-approved GLP-1 receptor agonists include semaglutide (Wegovy, Ozempic), tirzepatide (Mounjaro, Zepbound), liraglutide (Saxenda, Victoza), dulaglutide (Trulicity), and exenatide (Byetta, Bydureon)

Approval was backed by the ATTAIN program, including ATTAIN-1 (n= 3127), where Foundayo showed weight loss of 27.3 lbs (12.4%) vs 2.2 lbs (0.9%) with PBO at the highest dose, with overall loss of 25 lbs (11.1%) vs 5.3 lbs (2.1%), alongside reductions in CV risk markers across all doses About Foundayo (orforglipron) Foundayo is a once-daily small molecule (non-peptide) oral glucagon-like peptide-1 receptor agonist that can be taken any time of the day without restrictions on food and water intake