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Methods Modeling Approach Clinical and cost outcomes were projected over patient lifetimes (up to 60 years from a sampled baseline age of 56 years, thereby capturing all patient mortality) using the PRIME T2D Model [20]

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Lambs: 0.5mL at marking or weaning Sheep: 11.5mL pre-lambing Calves: 23mL from 2 months of age Cattle: 46mL pre-calving Active Ingredient: Hydroxocobalamin (Vitamin B12) Registered by Elanco Australasia Pty Ltd.

A sensitivity analysis was performed, in which all subjects who were receiving an SGLT2i or a GLP1RA at baseline or initiated such therapies during the trial were excluded