hydrochlorothiazide and semaglutide Ziac (Bisoprolol Fumarate, Hydrochlorothiazide) Hydrochlorothiazide Tablets IP (25 mg)

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30 In adolescents with obesity, semaglutide 2.4 mg once weekly led to weight loss similar to that observed in adults (a 16.1% mean reduction in BMI from baseline vs 0.6% with placebo at 68 weeks), along with improvements in cardiometabolic risk factors such as waist circumference, glycated haemoglobin (HbA 1c ), LDL-cholesterol, triglyceride and alanine transaminase levels

The trial focused on: Percentage of body weight lost Changes in blood sugar levels Shifts in blood pressure Tolerability at different doses, including the highest dose Safety over a longer treatment period This approach helped determine how the Eli Lilly weight-loss study compares to earlier GLP-1 research

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