R Clinical implications of slow acetylation: Increased risk of isoniazid-induced hepatotoxicity and peripheral neuropathy (tuberculosis treatment) R Increased risk of sulfonamide hypersensitivity reactions R Increased risk of aromatic amine-related bladder cancer in occupational exposure settings (dye workers, rubber industry) R Drug-induced lupus from hydralazine and procainamide occurs almost exclusively in slow acetylators R Altered caffeine metabolism (slow acetylators clear caffeine more slowly via the NAT2 pathway) R NAT1 polymorphisms are less well characterized but the slow allele NAT1*14 has been associated with increased risk of cancers from dietary aromatic amines
Conclusions: This study revealed an association of downregulated expression of PRDX5 and SOD2 in sperm samples of patients with idiopathic primary male infertility
Whole-Cell ELISA Whole-cell ELISA was performed as described previously ( M Cell-Targeting Property Analysis The M cell-targeting properties of LL-plSAM-FVpE and the SAM-FVpE protein were performed as described previously with slight modifications ( Prophylactic and Therapeutic Immunization For prophylactic immunization ( Figure 1A ), the SPF BALB/c mice (6 to 8 weeks old, male) were randomly divided into 4 groups (n = 10): LL-plSAM-FVpE, LL-plSAM, SAM-FVpE plus PA adjuvant, and SAM plus PA adjuvant
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