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Administration of L-carnitine as an adjunct to DMARDs therapy over a 12-week period resulted in significant reductions in CRP levels, morning stiffness, pain intensity measured via VAS, TJC, DAS28 score, and MHAQ score

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Similarly, oral trimetazidine (20 mg three times a day) among volunteers with diabetes and idiopathic dilated cardiomyopathy maintained CRP levels stable over 6 months compared to a placebo control that showed increased CRP [163]