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Even though many tumors overexpress GST P1-1 11, 35, 36 it is not obvious that the elevation is sufficient to compensate for the relatively low activity of this enzyme in comparison with other GSTs and make the neoplastic cells selectively vulnerable to release of NO from JS-K

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But chronic psychological stress does elevate cortisol levels, which can impair ovarian blood flow, disrupt hormonal signalling, and increase systemic oxidative stress, all of which may affect the follicular environment. While acute stress is unlikely to damage egg quality, prolonged or severe stress may compound the effects of other risk factors