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This intermediate is nucleophilically attacked by the active site tyrosine residue (Tyr114) to form a covalent vinylether adduct, leading to inhibition of the enzyme (Figure 6A) (Yadav et al., 2019)

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These results underscore the relative safety of A1AT replacement therapy, despite the severity of the underlying condition and the limited population of patients receiving this treatment

de S SVM, Faria MA, Fernandes JO, Cunha SC (2024) In vitro digestion and intestinal absorption of mycotoxins due to exposure from breakfast cereals: implications for childrens health