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JAMA 317 , 606614 (2017)

Sure enough, a popular sports medicine site confirms: Athletes with sickle cell trait are potentially more vulnerable to other serious conditions such as gross hematuria, splenic infarction, exertional heat stroke, severe muscle breakdown (rhabdomyolysis) and potentially even sudden death when participating in strenuous exercise under intense environmental conditions. Short of these devastating problems, which occur rarely with just the trait, more common symptoms may include muscle cramping/pain