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In a systematic review by Filippou et al., a mean reduction of 1.5 mmHg in both systolic and diastolic BP across 30 MedDiet intervention studies was estimated, an effect associated with a 20%25% reduction in major cardiovascular events [18], comparable to pharmacologic treatment benchmarks outlined in the Systolic Blood Pressure Intervention Trial (SPRINT) and Heart Outcomes Prevention Evaluation (HOPE) trials [19]

Effect of subcutaneous Tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: the SURPASS-5 randomized clinical trial